Stress and Other Risk Factors in Aging and Cancer: An AACR Innovation Summit

3:00 p.m.

Arrivals – The Langham Huntington

3:00 p.m.

Registration Opens – Foyer

6:00 p.m.

Welcome Dinner – Salon II

6:45 p.m.

Opening Remarks – Salon I

Margaret Foti, PhD, MD (hc) – Chief Executive Officer, American Association for Cancer Research

David A. Tuveson, MD, PhD, FAACR – Director and Roy J. Zuckerberg Professor of Cancer Research, Cold Spring Harbor Laboratory Cancer Center

7:00 p.m.

Keynote Address – Salon I

Andrea Alimonti, MD – Director, Institute of Oncology Research, Switzerland – Pros & Cons of Senescence in Cancer and Cancer Therapy

7:45 p.m.

Coffee/Tea and Dessert – Salon I

7:30 – 8:30 a.m.

Breakfast (60 min) – Salon II

8:30 – 8:45 a.m.

Welcome and Introduction to Summit Theme (15 min) – Salon I

Moderator: Sandra S. McAllister, PhD – Brigham And Women’s Hospital and Harvard Medical School

8:45 – 10:15 a.m.

Session 1: Age, Stress and Vulnerable Populations (90 min) – Salon I

Chair: Electra D. Paskett, PhD, MPH, FAACR – The Ohio State University

Introduction (5 min)

Speakers:

Format: 17 min each (10 min presentation followed by 7 min Q&A)

Electra D. Paskett, PhD, MPH, FAACR – The Ohio State University – Age, Stress and Vulnerable Populations

Kira Bona, MD, MPH – Boston Children’s Hospital and Dana-Farber Cancer Institute – Poverty as a “Druggable” Target: A Pediatric Oncology Framework for Investigating Outcome Disparities

Robert A. Winn, MD, FAACR – Virginia Commonwealth University – Premature Cellular Aging and Cancer: A Socio-Molecular Perspective

Adana A.M. Llanos, PhD, MPH – Columbia University Irving Medical Center – Stress, Place, and Breast Cancer: Linking Social and Structural Contexts to Biological Mechanisms

Carolyn J. Presley, MD, MHS – The Ohio State University – Resiliency among Older Adults with Lung Cancer

10:15 – 10:25 a.m.

Lightning Talks I and II (10 min) – Salon I

Format: 4 min each (2 min talk followed by 2 min Q&A)

Curtis J. Henry, PhD – University of Colorado Anschutz – Interleukin-37 Rejuvenates the Function of Aged Endogenous and CAR T-cells

Chloe M. Hery, PhD – The Ohio State University – Biological Aging, Stress, and Sleep in Rural Breast Cancer Patients

10:25 – 10:45 a.m.

Break (20 min) – Foyer

10:45 a.m. – 12:15 p.m.

Session 2: Senescence and Cellular Stress Driving Cancer (90 min) – Salon I

Chair: Sheila A. Stewart, PhD – Washington University in St. Louis

Introduction (5 min)

Speakers:

Format: 17 min each (10 min presentation followed by 7 min Q&A)

Peter D. Adams, PhD – Sanford Burnham Prebys Medical Discovery Institute – The Role of Aging in Cancer: New Insights from New Models

Darren J. Baker, PhD, MS – Mayo Clinic – Context-Dependent Roles of Senescent Cell Lineage in Shaping Cancer Progression

Hariharan P. Easwaran, PhD, MSc – Johns Hopkins University – Altered Oncogenic Stress Responses in Aged Stem Cells: Their Role in Promoting Tumor Development

Corina Amor Vegas, MD, PhD – Cold Spring Harbor Laboratory Cancer Center – Deconstructing the Interplay Between Cancer and Aging With Senolytic CAR T Cells

Mina S. Sedrak, MD, MS – University of California, Los Angeles – Targeting Senescence in the Clinic: Challenges and Opportunities

12:15 – 12:25 p.m.

Lightning Talks III and IV (10 min) – Salon I

Format: 4 min each (2 min talk followed by 2 min Q&A)

Julio A. Aguirre-Ghiso, PhD – Albert Einstein College of Medicine – When Age-Driven Mosaic Mutations in Blood Cells Stir Sleeping Cancer Cells

Xue-Yan He, PhD – Washington University in St. Louis – Conquering Stress in Cancer: Understanding the “Stressed Gut Feeling”

12:25 – 1:25 p.m.

Lunch (60 min) – Salon II

1:25 – 1:40 p.m.

Session 3: Lifestyle and Behavioral Factors Influencing Aging and Cancer (90 min) – Salon I

Lightning Talks V, VI and VII (15 min) – Salon I

Format: 4 min each (2 min talk followed by 2 min Q&A)

Alberto Bardelli, PhD – University of Torino and IFOM ETS The AIRC Institute of Molecular Oncology, Milan – Defining the Chronological Age of Tumors at Diagnosis

Iwalola A. Awoyinka, PhD – Medical College of Wisconsin Cancer Center – Integrating Community and Cultural Contexts in the Biology of Stress and Cancer Survivorship

Lucy A. Godley, MD, PhD – Northwestern University Feinberg School of Medicine – Age-Associated Clonal Hematopoiesis and Its Impact on Health

1:40 – 3:10 p.m.

Session 3: Lifestyle and Behavioral Factors Influencing Aging and Cancer (90 min) – Salon I

Chair: Judith E. Carroll, PhD – University of California, Los Angeles

Introduction (5 min)

Speakers:

Format: 17 min each (10 min presentation followed by 7 min Q&A)

Judith E. Carroll, PhD – University of California, Los Angeles – How Do Biobehavioral Factors Impact Aging Biology and Cancer Survivorship? A Conversation About Possible Mechanism

Elizabeth M. Cespedes Feliciano, ScD, SM – Kaiser Permanente Northern California – Body Composition and Aging in Cancer Survivors: Tumor Microenvironment to Population Risk

Michael H. Antoni, PhD – University of Miami – Stress, Stress Management and Aging in Breast Cancer:  Effects on Anti-Viral Immunity and T and B-Cell Hypermetabolism in Distressed Older Women Undergoing Breast Cancer Treatment

Jeanne S. Mandelblatt, MD, MPH – Georgetown University – Effect of Chronic Stressors on Aging Phenotypes and Biology: Implications for Survivorship Disparities

3:10 – 3:30 p.m.

Break (20 min) – Foyer

3:30 – 5:00 p.m.

Special Session on Aging and Stress Models (90 min)

Chair: Olga Anczuków, PhD – The Jackson Laboratory

Introduction (5 min) – Salon I

Speakers:

Format: 17 min each (10 min presentation followed by 7 min Q&A)

Vera Gorbunova, PhD – University of Rochester – Lessons From Long-Lived and Cancer-Resistant Mammals

Alexander Muir, PhD – University of Chicago – Incorporating Tumor Microenvironmental Stress in Cancer Models

Ron Korstanje, PhD – The Jackson Laboratory – The Genetic and Aging Influences on Neoplastic Susceptibility (GAINS) Study

Erica K. Sloan, PhD – Monash University, Australia – Preclinical Models of Stress and Cancer

Sheng Li, PhD – University of Southern California – Intrinsic Aging Drives Clonal Fitness in Hematopoietic Stem Cells

5:00 – 5:20 p.m.

Break (20 min) – Foyer

5:20 – 6:35 p.m.

Breakout Sessions (75 min) – Colonnade, Pavilion and Plaza
Sessions 1-3 (separate breakout for each)
6 speakers from sessions 1-3 with additional participants (Task Force, ESI, Models, Journal Editor) = 15 people per breakout

Dinner on own

7:00 – 8:00 a.m.

Breakfast (60 min) – Salon II

8:00 – 09:30 a.m.

Session 4: Metabolic Changes With Age and Their Impact on Cancer (90 min) – Salon I

Chair: Ana P. Gomes, PhD – Moffitt Cancer Center

Introduction (5 min)

Speakers:

Format: 17 min each (10 min presentation followed by 7 min Q&A)

Peter J. Mullen, PhD – University of Southern California – Metabolic Drivers of Aging

Katherine M. Aird, PhD – The Wistar Institute – Tumor and Senescent Cell Crosstalk via Metabolites

Alexandra M. Binder, ScD – University of Hawaii Cancer Center – Metabolic Aging and Treatment Response: Epigenetic Markers of Risk and Resilience

Cornelia M. Ulrich, MS, PhD – The University of Utah – Body Composition Alterations and Metabolic Changes in Colorectal Cancer Patients – Impact and Opportunities

Martine Extermann, MD, PhD – Moffitt Cancer Center – Addressing the Macro-Environment, Aka the Patient

09:30 – 09:40 a.m.

Lightning Talks VIII and IX (10-min) – Salon I

Format: 4 min each (2 min talk followed by 2 min Q&A)

Sheetal Hardikar, MBBS, MPH, PhD – The University of Utah – Geriatric Syndromes, Metabolic Aging, and Lifestyle Factors: Impact on Colorectal Cancer Outcomes

Stanislav Drapela, PhD – Moffitt Cancer Center – Bridging Cancer and Aging: Novel Therapeutic and Methodological Insights

09:40 – 10:00 a.m.

Break (20 min) – Foyer

10:00 – 11:30 a.m.

Session 5: Factors and Co-Morbidities that Accelerate Aging and Cancer (90 min) – Salon I

Chair: Victoria L. Seewaldt, MD – City of Hope

Introduction (5 min)

Speakers:

Format: 17 min each (10 min presentation followed by 7 min Q&A)

Mark A. LaBarge, PhD – City of Hope – Tissues Tell Time: Biological Aging Signatures That Predict Breast Cancer Risk

Sandra S. McAllister, PhD – Brigham And Women’s Hospital and Harvard Medical School – Accounting for Age in Breast Cancer Research and Discovery

Zhaoming Wang, PhD – St. Jude Children’s Research Hospital – Accelerated Aging in Survivors of Childhood Cancer

Victoria L. Seewaldt, MD – City of Hope – Insulin Resistance, Epigenetic Damage, and Accelerated Aging

Andrew E. Chapman, DO, FACP – Thomas Jefferson University – The Aging and Cancer Survivorship Dilemma

11:30 – 11:35 a.m.

Lightning Talk X (5-min) – Salon I

Format: 4 min (2 min talk followed by 2 min Q&A)

Stefan Hinz, PhD – City of Hope – MechanoAge: A Machine Learning Platform to Identify Individuals Susceptible to Breast Cancer Based on Mechanical Properties of Single Cells

11:35 a.m. – 12:35 p.m.

Lunch (60 min) – Salon II

12:35 – 2:05 p.m.

Session 6: Impact of Immune Aging on Cancer and Therapeutic Responses (90 min) – Salon I

Chair: Sandra S. McAllister, PhD – Brigham and Women’s Hospital and Harvard Medical School

Introduction (5 min)

Speakers:

Format: 17 min each (10 min presentation followed by 7 min Q&A)

Donna L. Farber, PhD – Columbia University – Immune Aging in Tissue Compartments

Ana P. Gomes, PhD – Moffitt Cancer Center – Tumor-Infiltrating CD8 T Cells Through the Lens of Old Age

James V. DeGregori, PhD – University of Colorado Anschutz – The Influence of Age on Somatic Evolution and Consequences for Health and Disease

Sheila A. Stewart, PhD – Washington University in St. Louis – Age-Related Versus Acute Stress-Related Senescence and Their Impact on Tumorigenesis and Therapy-Induced Toxicities

Cosimo Commisso, PhD – Sanford Burnham Prebys Medical Discovery Institute – Strategies for Dissecting the Role of the Aging Microenvironment in Cancer

2:05 – 2:15 p.m.

Lightning Talks XI and XII (10-min) – Salon I

Format: 4 min each (2 min talk followed by 2 min Q&A)

Peter van Galen, PhD – Brigham and Women’s Hospital and Harvard Medical School – An Inflammatory and Quiescent HSC Subset Expands With Age in Humans

Alison E. Ringel, PhD – Massachusetts Institute of Technology – Effects of Age-Related T Cell Decline on Tumor-Specific Immune Responses

2:15 – 2:35p.m.

Break (20 min) – Foyer

2:35 – 3:50 p.m.

Breakout Sessions (75 min) – Colonnade, Pavilion and Plaza
Sessions 4-6

6 speakers from sessions 4-6 with additional participants (Task Force, ESI, Models, Journal Editor)

3:50 – 4:10 p.m.

Break (20 min) – Foyer

4:10 – 6:10 p.m.

Wrap up – Breakout Groups Report Back (120 min) – Salon I

20 min each

6:10 – 6:30 p.m.

Closing Remarks – Salon I

David A. Tuveson, MD, PhD, FAACR – Director and Roy J. Zuckerberg Professor of Cancer Research, Cold Spring Harbor Laboratory Cancer Center

Dinner on own

8:00 – 09:00 a.m.

Breakfast – Salon II

11:00 a.m.

Departures